Etomoxir (CAS NO.: ), with its systematic name of Ethyl (+)-(R)-2-(6-(p-chlorophenoxy)hexyl)glycidate, could be produced through many synthetic methods.

Following are some of the synthesis routes:
Route one:
Alkylation of (II) with 1 6-di (I) results in diethyl 6-bromohexylmaionate (III). Compound (II) is hydrolyzed to the monoester (IV), followed by condensation with paraformaldehyde in ethanol/piperidine/ to yield ethyl 8-bromo-2-methyleneoctanoate (V), which is oxidized with permaleic acid to (VI). Subsequent reaction with 4-chlorophenolate produces etomoxir.

Route two:
Alkylation of 4-chlorophenol with 1,6-dibromohexane (I) produces 1 bromo-6-(4-chlorophenoxy)hexane (VII). Diethyl malonate (II) is alkylated by (VII), yielding (VIII), followed by hydrolysis to the monoester (IX), which is condensed with para formaldehyde/pyridine/piperidine to give ethyl 8-(4-chlorophenoxy)-2-methyleneoctanoate (IX). Oxidation with m-chloroperbenzoic acid produces etomoxir.