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Disodium malonate
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Name

Disodium malonate

 EINECS 205-514-0
CAS No. 141-95-7 Density 2.08 g/cm3
PSA 80.26000 LogP -3.12370
Solubility 1 M at 20 °C, clear, colorless in water Melting Point N/A
Formula C3H2Na2O4 Boiling Point 386.8 °C at 760 mmHg
Molecular Weight 148.026 Flash Point 201.9 °C
Transport Information N/A Appearance white crystalline powder
Safety 22-24/25 Risk Codes N/A
Molecular Structure Molecular Structure of 141-95-7 (MALONIC ACID DISODIUM SALT) Hazard Symbols N/A
Synonyms

Malonicacid, disodium salt (8CI);Propanedioic acid, disodium salt (9CI);Disodiummalonate;Sodium malonate;

Article Data 4

Disodium malonate Synthetic route

141-82-2

malonic acid

1310-73-2

sodium hydroxide

141-95-7

sodium malonate

Conditions
ConditionsYield
In water neutralization reaction with stoich. amt. at pH 6-7;

sodium α-sodium acetate

124-38-9

carbon dioxide

141-95-7

sodium malonate

Na2[Cu(malonate)2(H2O)2]

79-19-6

thiosemicarbazide

A

C2H10CuN6S2(2+)*C3H2O4(2-)

B

141-95-7

sodium malonate

Conditions
ConditionsYield
In water
141-95-7

sodium malonate

98-88-4

benzoyl chloride

A

93-97-0

benzoic acid anhydride

B

65-85-0

benzoic acid

Conditions
ConditionsYield
With Pyridine 1-oxide hydrochloride In dichloromethane; water at 18℃; Rate constant;A 13%
B 87%
290-37-9

1,4-pyrazine

cadmium(II) nitrate tetrhydrate

141-95-7

sodium malonate

[Cd(μ-malonato)(μ-pyrazine)0.5(H2O)](n)

Conditions
ConditionsYield
With tetramethylammonium chloride In water a soln. of Cd salt reated with a soln. of sodium malonate, stirred for 10 min, an aq. mixt. of pyrazine and tetramethylammonium chloride added slowly; filtered, crystd. for 1 wk in an open atmosphere, sepd., washed (H2O), dried; elem. anal.;85%

(η5-cyclopentadienyl)(dicarbonyl){(2R,5S,6S)-(3,4,5-η)-2-(acetoxymethyl)-6-ethoxy-5,6-dihydro-2H-pyran-5-yl}molybdenum

141-95-7

sodium malonate

(η5-cyclopentadienyl)(dicarbonyl){(2R,3R,6S)-(3,4,5-η)-2-(acetoxymethyl)-6-(1,3-dioxo-1,3-dimethoxy-2-propyl)-5,6-dihydro-2H-pyran-5-yl}molybdenum

Conditions
ConditionsYield
In tetrahydrofuran under Ar; addn. of freshly prepared sodium malonate in THF to suspn. of Mo-complex in THF (molar ratio 3:1, stirred, 0°C), stirred (15 min, 0°C), quenched (satd. NH4Cl soln.); extn. (CH2Cl2, three times), drying (over Na2SO4), filtration, concn., flash chromy. (1:1 degassed hexanes/ethyl acetate), recrystn. (degassed hexanes/CH2Cl2); elem. anal.;82%
21264-30-2, 14592-56-4, 90243-59-7

trans-bis(acetonitrile)palladium(II) chloride

7732-18-5

water

141-95-7

sodium malonate

sodium cis-dichloromalonatopalladate(II) dihydrate

Conditions
ConditionsYield
at 20℃;82%
4916-57-8

1,2-bis(4'-pyridyl)ethane

141-95-7

sodium malonate

Cu(NO3)2.3H2O

Cu(NO3)2.3H2O

polymer, [{Cu3(malonate)2{1,2-bis(4-pyridyl)ethane}3(H2O)2}(NO3)2(H2O)2]n, 3D open framework, organic-inorganic hybrid; monomer(s): disodium malonate; 1,2-bis(4-pyridyl)ethane; Cu(NO3)2

polymer, [{Cu3(malonate)2{1,2-bis(4-pyridyl)ethane}3(H2O)2}(NO3)2(H2O)2]n, 3D open framework, organic-inorganic hybrid; monomer(s): disodium malonate; 1,2-bis(4-pyridyl)ethane; Cu(NO3)2

Conditions
ConditionsYield
Stage #1: sodium malonate; Cu(NO3)2.3H2O In methanol; water for 0.5h;
Stage #2: 1,2-bis(4'-pyridyl)ethane In methanol; water for 4h; Heating; Further stages.;		80%
66-71-7

1,10-Phenanthroline

manganese(II) chloride tetrahydrate

7732-18-5

water

141-95-7

sodium malonate

[Mn(II)2(malonate)(1,10-phenanthroline)3(H2O)2Cl]Cl

Conditions
ConditionsYield
In methanol; water aq. soln. of malonate was added dropwise to MeOH soln. of Mn salt with stirring for 30 min, to this mixt. MeOH soln. of phenanthroline was addedslowly and stirred for 2 h, then refluxed for 6 h; mixt. was cooled, filtered, filtrate was kept in CaCl2-desiccator for several days, ppt. was filtered off, washed and dried; elem. anal.;80%
553-26-4

4,4'-bipyridine

manganese(II) chloride tetrahydrate

141-95-7

sodium malonate

[Mn2(malonate)2(H2O)2(4,4'-bipyridine)]n

Conditions
ConditionsYield
In methanol; water soln. MnCl2*4H2O in MeOH was allowed to react with aq. soln. disodium malonate for 20 min, MeOH soln. 4,4'-bipy was added and stirred for 2 h; soln. was filtered and evapd. slowly, crystals were filtered off, washedwith 2-propanol and dried; elem. anal.;80%

Disodium malonate Chemical Properties

IUPAC Name: Disodium propanedioate (141-95-7)
Synonyms: Malonicacid,sodiumsalt ; Sodiumpropanedioate ; Sodium malonate ; Sodium malonite ; Propanedioic acid disodium salt ; Methanedicarboxylic acid disodium salt ; Malonic acid disodium salt ; Disodium malonate
Molecular Structure:  
Molecular Formula : C3H2Na2O4
Molecular Weight:  148.03
CAS :  141-95-7
EINECS:  205-514-0
Flash Point: 201.9 °C 
Enthalpy of Vaporization: 69.8 kJ/mol 
Boiling Point: 386.8 °C at 760 mmHg 
Vapour Pressure: 4.66E-07 mmHg at 25°C 
solubility  H2O: 1 M at 20 °C, clear, colorless
Stability: Stable. Incompatible with strong oxidizing agents.
Appearance: Sodium malonate (141-95-7) is white crystalline powder
Solution:Soluble in water, insoluble in alcohol, ether and benzene.

Disodium malonate Uses

Sodium malonate (141-95-7) is used for raw material of pharmaceutical, dye and fragrance ; organic synthesis.

Disodium malonate Production

Derive by mixing malonic acid with sodium hydroxide solution; Industrial production often add chloroacetic acid with sodium cyanide to get cyanuric acid, and then through the role of liquid caustic soda sodium malonate. The chloroacetic acid dissolved in water at 15 ℃ below with saturated sodium carbonate solution  to pH7.0, and then adding sodium cyanide solution at 45 ℃, at 105-110 ℃ reaction to 30min, adding 45-55% sodium hydroxide,  reaction at the 100-105 ℃ 1.5h, concentrated solution of sodium malonic too dry to obtain Sodium malonate (141-95-7).

Disodium malonate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1550mg/kg (1550mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 461, 1949.
mouse LD50 intravenous 2100mg/kg (2100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

CARDIAC: OTHER CHANGES		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 461, 1949.
rabbit LD50 intravenous 660mg/kg (660mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 461, 1949.
rabbit LDLo subcutaneous 1584mg/kg (1584mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

ENDOCRINE: HYPERGLYCEMIA		 Journal of Biological Chemistry. Vol. 161, Pg. 55, 1945.
rat LD50 intraperitoneal 1100mg/kg (1100mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 17, Pg. 814, 1965.

Disodium malonate Safety Profile

Safety Statements:  22-24/25
22: Sodium malonate (141-95-7) is harmful if swallowed
24/25:  Toxic in contact with skin and if swallowed
WGK Germany:  3
RTECS:  OO1750000

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