Bioorganic and Medicinal Chemistry Letters p. 6643 - 6646 (2007)
Update date:2022-09-26
Topics:
Moon, Byung Seok
Park, Moon-Taek
Park, Jeong Hoon
Kim, Sang Wook
Lee, Kyo Chul
An, Gwang Il
Yang, Seung Dae
Chi, Dae Yoon
Cheon, Gi Jeong
Lee, Su-Jae
Eight d-ribo-phytosphingosine derivatives were synthesized from d-ribo-phytosphingosine and diverse acyl chlorides with N,N-diisopropylethylamine in tetrahydrofuran for 1 h at room temperature. Effect of these compounds on IR-induced cell death was evaluated on blood cancer cells (Jurkat). Among these, 3d showed the highest enhancement of radiosensitizing effect.
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Doi:10.1016/j.bmcl.2007.10.016
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(2007)