Preparation of 5-substituted 2-methyl-1,3,4-oxadiazoles from 5- substituted tetrazoles and acetic anhydride

Article abstract of DOI:10.1080/00397919408010158

Readily available tetrazoles can be transformed into the corresponding 2- methyl-1,3,4-oxazodiazoles by heating their acetic anhydride solution. The procedure is simple, short, gives high yields, and is applicable to large scale syntheses.

Full text of DOI:10.1080/00397919408010158

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Synthetic Communications: An
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Preparation of 5-Substituted 2-
Methyl-1,3,4-oxadiazoles from
5-Substituted Tetrazoles and
Acetic Anhydride
Branko S. Jursic a & Zoran Zdravkovskif a b
a Department of Chemistry, University of New
Orleans New Orleans, Louisiana, 70148
b Insitute of Chemistry, University Cyril & Methodius,
Arhimedova 5, 91000, Skopje, Macedonia
Version of record first published: 23 Sep 2006
To cite this article: Branko S. Jursic & Zoran Zdravkovskif (1994): Preparation
of 5-Substituted 2-Methyl-1,3,4-oxadiazoles from 5-Substituted Tetrazoles and
Acetic Anhydride, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 24:11, 1575-1582
To link to this article: http://dx.doi.org/10.1080/00397919408010158
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