Tributylstannyl 4-tributylstannylbut-3-enoate: A useful C-4 homologating agent. Application to the synthesis of aryl iodolactones

Article abstract of DOI:10.1016/0040-4039(96)01725-X

Tributylstannyl 4-tributylstannylbut-3-enoate, readily prepared by radical hydrostannation, is used for the transfer of a but-3-enoic acid synthon. Some of the potentialities of this synthon are established by the synthesis of aryl iodolactones or tetralones (one of them is a key intemediate for ABT-200 synthesis).