Bulletin of the Chemical Society of Japan p. 1991 - 1999 (1985)
Update date:2022-08-04
Topics:
Tsuge, Otohiko
Tanaka, Junji
Kanemasa, Shuji
Fluoride-induced desilylation of (α-phthalimido-, α-morpholino-, and α-acetamidobenzyl)silanes and a (phthalimidomethyl)silane generates the corresponding α-amino carbanions which add to a variety of aldehydes.The conversion of phthalimido group of the adducts into amino moiety leads to β-amino alcohols.This simple reaction sequence offers a new and general method of nucleophilic aminomethylation.
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