Bioorganic and Medicinal Chemistry Letters p. 147 - 151 (2008)
Update date:2022-08-05
Topics:
Watson, Robert J.
Allen, Daniel R.
Birch, Helen L.
Chapman, Gayle A.
Galvin, Frances C.
Jopling, Louise A.
Knight, Roland L.
Meier, Dorica
Oliver, Kathryn
Meissner, Johannes W.G.
Owen, David A.
Thomas, Elizabeth J.
Tremayne, Neil
Williams, Sophie C.
The optimization of a series of 1-aryl-3-piperidinyl urea derivatives is described in which incorporation of tropenyl and homotropenyl moieties has led to significant improvements in activity and drug-like properties. Replacement of the central piperidine
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