Journal of Asian Natural Products Research p. 1074 - 1080 (2011)
Update date:2022-08-04
Topics:
Liang, Shuang
Feng, Yi
Tian, Jun-Mian
Lu, Min
Xiong, Zhi
Zhang, Wei-Dong
Chemical examination of the methanolic extract from the stem bark of Daphne feddei led to the isolation of three new dicoumarin glucosides (1-3), and eight known coumarins, dicoumarins and dicoumarin glucosides. Their structures were elucidated by extensive analysis of spectral data and comparison with the literature values. All compounds were tested for inhibitory activity against lipopolysaccharide-induced NO production in RAW 264.7 macrophages, and compounds 4 and 5 showed potent inhibitory activity with IC50 values of 0.161 and 0.127mM, respectively.
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