Bioorganic and Medicinal Chemistry Letters p. 355 - 359 (2008)
Update date:2022-08-04
Topics:
Nersesian, Diana L.
Black, Lawrence A.
Miller, Thomas R.
Vortherms, Timothy A.
Esbenshade, Timothy A.
Hancock, Arthur A.
Cowart, Marlon D.
Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine.
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