Bioorganic and Medicinal Chemistry Letters p. 710 - 715 (2008)
Update date:2022-08-04
Topics:
Faucher, Nicolas
Martres, Paul
Laroze, Alain
Pineau, Olivier
Potvain, Florent
Grillot, Didier
Starting from the structure of 5, a two-step strategy was applied to identify a new generation of trifluoromethane sulfonamides as potent PPARα agonists. Synthesis, in vitro and in vivo evaluation of the most potent compound are reported.
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