Zhuang-ping Zhan et al.
COMMUNICATIONS
by silica gel column chromatography (EtOAc/hexane) to
afford corresponding g-alkynyl ketone 3aa; yield: 0.108 g
(87%).
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Typical Procedure for the Synthesis of Substituted
Furans
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enoxysilane 2a (1.5 mmol, 0.195 g), CH3CN (1.0 mL) and
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Cu(OTf)2 (0.005 mmol, 0.002 g) were successively added,
U
the reaction mixture wastsirred at room temperature, and
monitored periodically by TLC. Upon reaction completion,
the solvent CH3CN was removed under reduced pressure by
an aspirator, followed by the addition of toluene (6.0 mL)
and
a stoichiometric amount of 4-toluenesulfonic acid
(0.5 mmol, 0.086 g). The reaction washeated to reflux and
monitored by TLC. When completed, toluene wasconcen-
trated under reduced pressure by an aspirator, and then the
residue was purified by silica gel column chromatography
(hexane) to afford the corresponding substituted furan 6ba;
yield: 0.088 g (77%).
Acknowledgements
The research was financially supported by the National Natu-
ral Science Foundation of China (NO. 30572250), the Nation-
al Natural Science Foundation of Fujian province of China
(NO. C0510002), the Program for New Century Excellent
Talents in Fujian Province University and the Program for
Innovative Research Team in Science and technology in
Fujian Province University.
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