Journal of Medicinal Chemistry p. 2464 - 2468 (1991)
Update date:2022-08-03
Topics:
Nickisch
Beier
Bittler
Elger
Laurent
Losert
Nishino
Schillinger
Wiechert
Several steroidal 6,6-ethylene-15,16-methylene 17-spirolactones were synthesized to find new progestogens that exhibit both progestational and antimineralocorticoidal activities. The influence of substituents in the 10- and 13-position of the steroidal framework on both properties was investigated. It was found that only compound 12, carrying methyl groups at the 10- and 13-positions, possesses high progestational and antimineralocorticoidal activity.
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