Folate Analogues. 25. Synthesis and Biological Evaluation of N10-Propargylfolic Acid and Its Reduced Derivatives

DOI: 10.1021/jm00157a600

Source and publish data:

Journal of Medicinal Chemistry p. 1263 - 1269 (1986)

Update date:2022-07-30

Topics:

Authors:

Ghazala, Maryam

Nair, M. G.

Toghiyani, Tahereh R.

Kisliuk, R. L.

Gaumont, Y.

Kalman, T. I.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00157a600

N¹⁰-Propargylfolic acid (2), which is the closest pteridine analogue of the thymidylate synthase inhibitor N¹⁰-propargyl-5,8-dideazafolic acid (PDDF), was synthesized starting from diethyl -L-glutamate (5

Full text of DOI:10.1021/jm00157a600

Products guided by the article

Product name:diethyl benzoyl>-L-glutamate

Cas No:101773-16-4

R&D Labs maybe for 101773-16-4

Jinan Boss Chemical Industry Co., Ltd.【revoke the business license】

website:http://www.chemboss.com.cn

Contact:+86-531-58591595

Address:No2.Hualong Road, Jinan, China
Shanghai Pinewood Fine Chemical Co., Ltd.

website:http://www.pinewoodchem.com

Contact:0086-21-62417129，62414096

Address:Suite B, 27F, No.2, Lane 600, Tianshan Road, Shanghai
SHANGHAI BIOSUNDRUG CO.,LTD.

Contact:86-21-34622192，13917187091，21-34622765

Address:No. 500 Caobao Road Shanghai P.R China
HANGZHOU GOPHER CHEM-TECH CO.,LTD

Contact:86-189-58111780

Address:Da Cheng Ming Zuo Plaza,Xiaoshan District
Wuhan Better Organic Technology Inc.

Contact:13307163183

Address:Wuhan Economic&Technology Development Zone, Hubei

Relevant to this article

Direct C-H bond activation: Palladium-on-carbon as a reusable heterogeneous catalyst for C-2 arylation of indoles with arylboronic acids

Doi:10.1039/d0nj00735h
(2020)
Phosphine containing dendrimers for highly regioselective rhodium catalysed hydroformylation of alkenes: A positive 'dendritic effect'

Doi:10.1039/b206597e
(2002)
Efficient ruthenium-catalysed S-S, S-Si and S-B bond forming reactions

Doi:10.1039/c3cc43145b
(2013)
Doi:10.1021/ja01495a011
(1960)
Artificial photosynthesis of methanol from carbon dioxide and water via a Nile red-embedded TiO₂ photocathode

Doi:10.1039/c6ta10231j
(2017)
Doi:10.1007/BF00899906
(1954)

Article Doi