Folate Analogues. 25. Synthesis and Biological Evaluation of N10-Propargylfolic Acid and Its Reduced Derivatives

DOI: 10.1021/jm00157a600

Source and publish data:

Journal of Medicinal Chemistry p. 1263 - 1269 (1986)

Update date:2022-07-30

Topics:

Authors:

Ghazala, Maryam

Nair, M. G.

Toghiyani, Tahereh R.

Kisliuk, R. L.

Gaumont, Y.

Kalman, T. I.

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Article abstract of DOI:10.1021/jm00157a600

N¹⁰-Propargylfolic acid (2), which is the closest pteridine analogue of the thymidylate synthase inhibitor N¹⁰-propargyl-5,8-dideazafolic acid (PDDF), was synthesized starting from diethyl -L-glutamate (5

Full text of DOI:10.1021/jm00157a600

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