Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors

DOI: 10.1016/j.bmc.2007.10.061

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1359 - 1375 (2008)

Update date:2022-08-04

Topics:

Authors:

Mulvihill, Mark J.

Ji, Qun-Sheng

Coate, Heather R.

Cooke, Andrew

Dong, Hanqing

Feng, Lixin

Foreman, Kenneth

Rosenfeld-Franklin, Maryland

Honda, Ayako

Mak, Gilda

Mulvihill, Kristen M.

Nigro, Anthony I.

O'Connor, Matthew

Pirrit, Caroline

Steinig, Arno G.

Siu, Kam

Stolz, Kathryn M.

Sun, Yingchuan

Tavares, Paula A.R.

Yao, Yan

Gibson, Neil W.

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Article abstract of DOI:10.1016/j.bmc.2007.10.061

A series of novel, potent quinolinyl-derived imidazo[1,5-a]pyrazine IGF-IR (IGF-1R) inhibitors-most notably, cis-3-(3-azetidin-1-ylmethylcyclobutyl)-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-ylamine (AQIP)-is described. Synthetic details, structure

Full text of DOI:10.1016/j.bmc.2007.10.061

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Product name:3-cyclobutyl-1-(2-phenyl-quinolin-7-yl)-imidazol[1,5-a]pyrazin-8-ol

Cas No:1018838-78-2

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