PREPARATION OF RIBONUCLEOSIDE 3'-O-PHOSPHORAMIDITES AND THEIR APPLICATION TO THE AUTOMATED SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDES

Article abstract of DOI:10.1016/S0040-4039(00)98753-7

Oligoribonucleotides, six to fifteen units long, were synthesized on a controlled pore glass support using ribonucleoside 3'-O-phosphoramidite reagents.Average coupling yields of up to 98percent were obtained with diisopropylaminophosphoramidite derivativ