Journal of the Chemical Society. Perkin transactions I p. 2189 - 2194 (1987)
Update date:2022-09-26
Topics: Synthesis Improved synthesis Experimental (+)-milbemycin β3 3,4-dihydro-2H-pyran
Kocienski, Philip J.
Street, Stephen D. A.
Yeates, Clive
Campbell, Simon F.
A more efficient synthesis of the title compound (2), previously used in a total synthesis of (+)-milbemycin β3 (1), is described.The key step in the sequence involves a nucleophilic cleavage of the oxirane (4) by the organocuprate derived from
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Doi:10.1016/S0040-4039(00)89288-6
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