Improved Cs2CO3 promoted O-alkylation of acids

Article abstract of DOI:10.1080/00397910008086893

Cesium carbonate mediated O-alkylation of carboxylic acids was efficiently carried out under mild in situ conditions to give the corresponding esters exclusively. Chiral templates including α-hydroxy and α-alkoxy acids were also converted to their corresponding esters with no observed racemization.

Full text of DOI:10.1080/00397910008086893

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Improved Cs2CO3 Promoted O-
Alkylation of Acids
Jay P. Parrish a , Eric E. Dueno a , Seok-In Kim a &
Kyung Woon Jung a
a Department of Chemistry, University of South
Florida & Drug Discovery Program, H. Lee Moffitt
Cancer Center & Research Institute, 4202 E. Fowler
Avenue, Tampa, Florida, 33620-5250, USA
Published online: 16 Feb 2011.
To cite this article: Jay P. Parrish , Eric E. Dueno , Seok-In Kim & Kyung Woon Jung
(2000): Improved Cs2CO3 Promoted O-Alkylation of Acids, Synthetic Communications:
An International Journal for Rapid Communication of Synthetic Organic Chemistry,
30:15, 2687-2700
To link to this article: http://dx.doi.org/10.1080/00397910008086893
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