Synthesis of enantiomerically pure functionalised amides (EPC-synthesis) from chiral β-aminated organolithium intermediates

DOI: 10.1016/S0040-4039(00)76980-2

Source and publish data:

Tetrahedron Letters p. 4831 - 4834 (1994)

Update date:2022-08-03

Topics: Enantiomerically pure Chiral Functionalised amides

Authors:

Foubelo, Francisco

Yus, Miguel

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Article abstract of DOI:10.1016/S0040-4039(00)76980-2

The successive deprotonation-lithiation of chiral chloroamides 1 with n-butyllithium and lithium naphthalenide, respectively, at -78°C leads to the corresponding chiral β-aminated organolithium intermediates 2, which by reaction with different electrophil

Full text of DOI:10.1016/S0040-4039(00)76980-2

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