Efficient phosphonium-mediated synthesis of 2-amino-1,3,4-oxadiazoles

DOI: 10.1021/ol8004084

Source and publish data:

Organic Letters p. 1755 - 1758 (2008)

Update date:2022-07-30

Topics:

Authors:

Levins, Christopher G.

Wan, Zhao-Kui

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Article abstract of DOI:10.1021/ol8004084

We present an efficient, room temperature procedure for the preparation of 2-amino-1,3,4-oxadiazoles. Oxadiazol-2-ones can be activated for S_nAr substitution using phosphonium reagents (e.g., BOP). This approach provides convenient access to N,

Full text of DOI:10.1021/ol8004084

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