Nucleotides; Part XXXVI A New Synthesis of 9-(β-D-Ribofuranosyl)uric Acid and its 5'-Monophosphate

DOI: 10.1002/hlca.19870700126

Source and publish data:

Helvetica Chimica Acta p. 210 - 218 (1987)

Update date:2022-08-03

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Authors:

Schulz, Bernd S.

Pfleiderer, Wolfgang

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Article abstract of DOI:10.1002/hlca.19870700126

Syntheses for 9-(β-D-ribofuranosyl)uric acid (16) and its 5'-monophosphate 14 have been achieved starting from guanosine and applying the 2-(?-nitrophenyl)ethyl group for protection of the aglycon moiety as well as the phosphate function.A more effficient and direct approach to 14 uses O⁶,O⁸-dibenzyl protection and phosphorylation by the Yoshikawa procedure.The various protected intermediates have been characterized by spectroscopic means and elemental analysis.

Full text of DOI:10.1002/hlca.19870700126

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