Nucleotides; Part XXXVI A New Synthesis of 9-(β-D-Ribofuranosyl)uric Acid and its 5'-Monophosphate

Article abstract of DOI:10.1002/hlca.19870700126

Syntheses for 9-(β-D-ribofuranosyl)uric acid (16) and its 5'-monophosphate 14 have been achieved starting from guanosine and applying the 2-(?-nitrophenyl)ethyl group for protection of the aglycon moiety as well as the phosphate function.A more effficient and direct approach to 14 uses O⁶,O⁸-dibenzyl protection and phosphorylation by the Yoshikawa procedure.The various protected intermediates have been characterized by spectroscopic means and elemental analysis.