Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors

Article abstract of DOI:10.1016/j.bmcl.2008.10.097

A series of analogs of 2-tosylnaphthalene-1,4-diol were prepared and were found to be potent 10-20 nM reversible inhibitors of the Escherichia coli FabH enzyme. The inhibitors were also effective but to a lesser degree (30 nM-5 μM), against the Mycobacter