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Novel c-2 substituted carbapenem derivatives. Part IV. Synthesis and biological activity of five membered heteroaromatic derivatives

DOI: 10.7164/antibiotics.51.210

Source and publish data:

Journal of Antibiotics p. 210 - 220 (1998)

Update date:2022-08-03

Topics:

Authors:

Branch, Clive L.Branch, Clive L.

Burton, GeorgeBurton, George

Clarke, Graham J.Clarke, Graham J.

Coulton, StevenCoulton, Steven

Douglas, James D.Douglas, James D.

Eglington, A. JohnEglington, A. John

Guest, Angela W.Guest, Angela W.

Hinks, Jeremy D.Hinks, Jeremy D.

Hird, Nicholas W.Hird, Nicholas W.

Holland, Rebecca K.Holland, Rebecca K.

Hunt, EricHunt, Eric

Knott, Sarah J.Knott, Sarah J.

Moss, Stephen F.Moss, Stephen F.

Naylor, AntoinetteNaylor, Antoinette

Pearson, Michael J.Pearson, Michael J.

Takle, Andrew K.Takle, Andrew K.

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Article abstract of DOI:10.7164/antibiotics.51.210

The synthesis, antibacterial activity, and stability to human dehydropeptidase-1 (DHP-1) of a novel series of (5R,6S)-6-[(1R)-1-hydroxyethyl]-2-heterocyclylcarbapen-2-em-3-carboxylates are described. Of the compounds investigated 1,5-disubstituted pyrazol

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Full text of DOI:10.7164/antibiotics.51.210

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