Chemical and Pharmaceutical Bulletin p. 1169 - 1176 (1997)
Update date:2022-09-26
Topics:
Tsuruoka, Akihiko
Kaku, Yumiko
Kakinuma, Hiroyuki
Tsukada, Itaru
Yanagisawa, Manabu
Naito, Toshihiko
A new series of thiazole-containing triazole antifungals was synthesized and evaluated for antifungal activity against a variety of clinically isolated pathogenic fungi in vitro and against systemic candidosis in vivo. Among these compounds, (±)-1-(2,4-difluorophenyl)-1-[4-(2,4- difluorophenyl)thiazol-2-yl]-2-(1H-1,2,4-triazol-1-yl)ethanol (ER24161) showed the most potent and well-balanced in vitro activities and excellent in vivo efficacy. We also achieved an enantioselective synthesis of the more potent enantiomer of ER-24161.
View MoreYancheng Smiling Imp & Exp Co., Ltd.
Contact:+86-515-83173586
Address:Rm1207, BLD#03, Phoenix Plaza, Juheng Road, Yancheng, Jiangsu, P.R. China
Onlychem (Jinan)Biotech Co.,Ltd
Contact:86-531-83175885
Address:No. 44, Honglou South Road, Jinan,China
Contact:0571-86821378 ,86820258,56836287,56830923,
Address:Block D ,20F, Tianyuan Building,No.508, Wensan RD, 310013,Hangzhou Zhejiang China
Contact:+86-28-88523492
Address:714rooms of Time Square, Pujiang County
Shandong Dayi Chemical Co., Ltd.
website:http://www.dayi.com.cn
Contact:+86- 535-7388728. 15306386031
Address:No 1 Danya west road, Laiyang City, Shandong province
Doi:10.1016/j.bmcl.2012.07.094
(2012)Doi:10.1016/S0040-4039(00)82121-8
(1988)Doi:10.1039/b910475e
(2009)Doi:10.1039/c2ob25115a
(2012)Doi:10.1055/s-1987-28162
(1987)Doi:10.1007/BF00763529
(1988)