Journal of Medicinal Chemistry p. 1537 - 1540 (1986)
Update date:2022-07-29
Topics:
Gill, Julie C.
Lockey, Peter M.
Marples, Brian A.
Traynor, John R.
Diastereoisomers of 3,17β-dihydroxy-20,21-epoxy-19-norpregna-1,3,5-(10)-triene have been prepared as potential antitumor agents.Both isomers undergo the base-catalyzed Payne rearrangement.The isomers were cytotoxic to mammalian cells in culture and were able to displace <3H>estradiol from binding sites in rat uterine cytosols with 1/7 and 1/70 the potency of estradiol.The reasons for this difference are discussed.
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