Asymmetric synthesis of unusual amino acids: Synthesis of optically pure isomers of N-indole-(2-mesitylenesulfonyl)-β-methyltryptophan

Article abstract of DOI:10.1016/S0040-4020(01)86957-X

We have developed methods for the synthesis of the four optically pure isomers of β-methyltryptopham with the 2-mesitylenesulfonyl indole protecting group for peptide synthesis. Starting from 3-indoleacrylic acid, the β-methyl function was generated by a