Amphimic acids, novel unsaturated C28 fatty acids as DNA topoisomerase I inhibitors from an Australian sponge amphimedon sp.

Article abstract of DOI:10.1016/S0040-4039(97)01234-3

Amphimic acids A (1) and B (2), novel unsaturated long-chain fatty acids possessing a cyclopropylidene group and inhibiting DNA topoisomerase I, have been isolated from an Australian sponge Amphimedon sp. Their structures were elucidated by spectroscopic analysis and chemical degradation. The enantioselective synthesis of 1 was carried out to determine the absolute configuration.