Total syntheses of makaluvamines A, B, C, D and E, cytotoxic pyrroloiminoquinone alkaloids isolated from marine sponge bearing inhibitory activities against topoisomerase II

Article abstract of DOI:10.1016/S0040-4020(01)85674-X

Syntheses of makaluvamines A, B, C, D and E (1-5), new members of tetrahydropyrroloiminoquinone alkaloids, have been successfully carried out. Particularly, olefin introduction for makaluvamines B and E could be achieved by Pd-mediated and E₂ t