Preparation of primary amines by the copper(I) catalyzed reaction of 4,4'-bis(trifluoromethyl)benzophenone O-methylsulfonyloxime and alkyl Grignard reagents

Article abstract of DOI:10.1246/cl.1997.317

Primary amines are prepared by the reaction of 4,4'-bis-(trifluoromethyl)benzophenone O-methylsulfonyloxime and alkyl Grignard reagents in the presence of a catalytic amount of CuCN-2LiCl and the successive acid hydrolysis of the resulting N-alkylimine derivatives.