Enhanced Brain Delivery of an Anti-HIV Nucleoside 2'-F-ara-ddI by Xanthine Oxidase Mediated Biotransformation

DOI: 10.1021/jm00032a017

Source and publish data:

Journal of Medicinal Chemistry p. 821 - 827 (1994)

Update date:2022-08-05

Topics:

Authors:

Shanmuganathan, Kirupa

Koudriakova, Tatiana

Nampalli, Satyanarayana

Du, Jinfa

Gallo, James M.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00032a017

In order to enhance the brain delivery of 2'-F-ara-ddI, 2'-F-ara-ddP 6 was synthesized and its in vitro and in vivo bioconversion reaction studied.For the study, a new efficient synthetic method for 2'-F-ara-ddP 6 was developed from 5-benzoyl-1,2-O-isopro

Full text of DOI:10.1021/jm00032a017

Products guided by the article

Product name:Benzoic acid (2S,4S,5R)-4-fluoro-5-purin-9-yl-tetrahydro-furan-2-ylmethyl ester

Cas No:1027658-35-0

R&D Labs maybe for 1027658-35-0

henan victory industry co.ltd

Contact:86-371-63655023

Address:No.85,jinshui road,zhengzhou,China
Wuhan Shangrisyn chemicals Technology Co.,Ltd(expird)

Contact:+86-027-84466317 __ +86-15387123698

Address:wuhan - china
Shandong General Materials Co.,Ltd（Shandong Aoertong Chemical Co., Ltd）

Contact:86-531-88072280

Address:No. 1825 Hualong Road, Licheng District, Jinan, Shandong, China
Chongqing Werlchem Fine Chemical Co. Ltd

Contact:+86-23-67521957

Address:NO.15,Fortune Road,Yubei District,401121,Chongqing,China
Amadis Chemical Co., Ltd.

website:http://www.amadischem.com

Contact:86-571-89925085

Address:Watts Cosine.No.166.Xiangmao Road.

Relevant to this article

Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H₄ receptor ligands

Doi:10.1021/jm8005959
(2008)
Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model

Doi:10.1021/jm701613h
(2008)
Studies on β-turn of peptides. XII. Synthetic confirmation of weak activity of [D-Pro(5,5')]-gramicidin S predicted from β-turn preference of its partial sequence

Doi:10.1246/bcsj.59.535
(1986)
A New Oxidation of 3-Bromocamphor to Camphorquinone

Doi:10.1246/cl.1994.1885
(1994)
Coralydine composition and Hofmann decomposition. Corydaline, synthesis from palmatine by recent methods.

Doi:10.1002/ardp.19602931006
(1960)
Cycloadditions of adamantanethione S-methylide to heteromultiple bonds

Doi:10.1016/S0040-4020(99)00664-X
(1999)

Article Doi