Enhanced Brain Delivery of an Anti-HIV Nucleoside 2'-F-ara-ddI by Xanthine Oxidase Mediated Biotransformation

DOI: 10.1021/jm00032a017

Source and publish data:

Journal of Medicinal Chemistry p. 821 - 827 (1994)

Update date:2022-08-05

Topics:

Authors:

Shanmuganathan, Kirupa

Koudriakova, Tatiana

Nampalli, Satyanarayana

Du, Jinfa

Gallo, James M.

et al. et al.

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Article abstract of DOI:10.1021/jm00032a017

In order to enhance the brain delivery of 2'-F-ara-ddI, 2'-F-ara-ddP 6 was synthesized and its in vitro and in vivo bioconversion reaction studied.For the study, a new efficient synthetic method for 2'-F-ara-ddP 6 was developed from 5-benzoyl-1,2-O-isopro

Full text of DOI:10.1021/jm00032a017

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