Mitomycin derivatives having unique condensed-ring structures. Their synthesis and antitumor activity

Article abstract of DOI:10.7164/antibiotics.47.1312

A series of mitomycin derivatives 1~3 having unique condenscd-ring structures was synthesized and evaluated for their anticellular and antitumor activity. These compounds were synthesized by the Michael addition of 1,3-dicarbonyl compounds to 6-demethyl-7