Opening of gem dicyano epoxides with amino hydrohalides: Application to the synthesis of structural analogs of tetramisole and biological evaluation

DOI: 10.1016/0223-5234(91)90064-T

Source and publish data:

European Journal of Medicinal Chemistry p. 313 - 321 (1991)

Update date:2022-07-30

Topics:

Authors:

Jaguelin

Robert Robert

Genetet Genetet

Gayral Gayral

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0223-5234(91)90064-T

α-halogenamides are prepared in a onepot reaction by reacting gem dicyano epoxides with amino hydrohalides. This original reactivity of gem dicyano epoxides is used to prepare substituted [2,1-b]imidazothiazoles which are structural analogs of tetramisole

Full text of DOI:10.1016/0223-5234(91)90064-T

Products guided by the article

Product name:2-Chloro-N-(4,5-dihydro-thiazol-2-yl)-2-p-tolyl-acetamide

Cas No:102862-42-0

R&D Labs maybe for 102862-42-0

zonk drug r&d limited

Contact:+86-20-32051076

Address:1105,Building A, International Business Incubator,Science City
Nanjing Legend Pharmaceutical & Chemical Co., Ltd.

Contact:+86-25-83767696

Address:14-7 Zhongshan Lu Guluo District, Nanjing
Zhejiang Haizhou Pharmaceutical Co., Ltd.

website:https://www.haizhoupharma.com/

Contact:+86-576-88221016

Address:No. 19, Donghai 5th Avenue, Yanhai Industrial Zone, Linhai, Zhejiang, China
shandong zhongke taidou chemical co.,ltd

Contact:86-531-88682301

Address:Jinan shandong Province CHina
H&Y International Group Ltd

Contact:+86-571-86491666

Address:SHI XIANG ROAD

Relevant to this article

First total synthesis and absolute configuration of naturally occurring (-)-hyacinthacine A₇ and its (-)-1-epi-isomer

Doi:10.1016/j.tet.2008.03.009
(2008)
HETEROADAMANTANES AND THEIR DERIVATIVES. 6. SYNTHESIS AND MASS-SPECTROMETRIC INVESTIGATION OF 5-MONO- AND 5,6-DISUBSTITUTED 6-OXO-1,3-DIAZAADAMANTANES

Doi:10.1007/BF00842964
(1985)
Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines

Doi:10.1016/j.bmc.2009.11.010
(2010)
Synthesis of bis-18,18′-desmethyl ritterazine N

Doi:10.1021/jo800454w
(2008)
Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents

Doi:10.1021/jm401208b
(2013)
The Use of Crown Ethers in Peptide Chemistry IV. Solid Phase Synthesis of Peptides Using Peptide Fragments Nα Protected With 18-Crown-6

Doi:10.1016/0040-4020(95)00206-N
(1995)

Article Doi