Journal of Medicinal Chemistry p. 1374 - 1380 (1986)
Update date:2022-08-05
Topics:
Kim, Chong-Ho
Marquez, Victor E.
Mao, David T.
Haines, David R.
McCormack, John J.
One of the problems encountered in the use of the tetrahydrouridine (THU, 2) and saturated 2-oxo-1,3-diazepine nucleosides as orally administered cytidine deaminase (CDA) inhibitors is their acid instability.Under acid conditions these compounds are rapid
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