Journal of the American Chemical Society p. 5962 - 5964 (1986)
Update date:2022-08-04
Topics:
Washburn, William N.
Cook, Ewell R.
Kinetic and 18O-labeling studies demonstrate that in the hydrolysis of nonenolizable acetoacetate esters, the carbonyl hydrate acts as a nucleophilic catalyst.A cyclic four-membered lactone is formed and later opens.Structure/reactivity studies showed the rate-determining step to be a function of the pKa of the leaving group and the substituent bound to C3 of the acetoacetate residue.Rate accelerations of 4 to E4 were observed for hydrolyses of the corresponding p-nitrophenyl esters, depending on the substituent at C3.
View MoreJiangxi Hessence Chemicals Co., Ltd.
Contact:+86 796 3511924
Address:Chengxi Industrial Park, Jishui County, Jiangxi Province 331600 China.
Contact:+86-22-83718541
Address:32th Floor, Rongqiao Center Intersection of Changjiang Road and Nankai Six Road Nankai District Tianjin 300102, China
Kaymossy BioChem Tech Co., Ltd
website:http://www.kaimosi.com
Contact:0571-87191913/0571-87199097
Address:Room 215, Building 3rd, No.288 Ningxia Road, Qingdao city, China
Shanghai Egoal Chemical Co.,Ltd
Contact:+86-21-50333091
Address:Yangming Garden Square 3,YangGao North Road 1188, Pudong New District, Shanghai
website:http://www.chinacharm.cn/
Contact:86 551 5316260
Address:No. 211,XiangZhang Road,Hefei City,Anhui Province,China
Doi:10.1039/c3dt52898g
(2014)Doi:10.1016/j.tet.2008.03.020
(2008)Doi:10.1021/om800122k
(2008)Doi:10.1016/S0040-4039(00)98887-7
(1985)Doi:10.1016/j.tetlet.2008.03.152
(2008)Doi:10.1039/c4tc02664k
(2015)
