α-ALKYLATION OF ACYCLIC AMINO ACIDS WITH SELF-REPRODUCTION OF THE CENTER OF CHIRALITY. A NEW ROUTE TO (S)-(+)-α-ALKYLATED ASPARTIC ACIDS.

Article abstract of DOI:10.1016/S0040-4039(00)96091-X

The amino acids 1a-d (alanine, phenylalanine, valine and methionine) are alkylated by ethyl bromoacetate, with inversion of configuration, to provide readily with high stereoselectivity the α-alkylated aspartic acids 9a-d through the chiral enolates 7a-d