Journal of Organic Chemistry p. 8556 - 8566 (2018)
Update date:2022-08-03
Topics:
Yu, Yongqi
Chen, Xiang
Wu, Qianlong
Liu, Da
Hu, Liang
Yu, Lin
Tan, Ze
Gui, Qingwen
Zhu, Gangguo
An efficient protocol for the synthesis of internal aryl alkynes was achieved via Cu-catalyzed decarboxylative cross-coupling reactions, and to the best of our knowledge, this is the first example of a Cu-catalyzed decarboxylative alkynylation of benzoic acids with terminal alkynes. This approach utilizes simple Cu salt as catalyst and O2, an abundant, clean, and green material, as the oxidant. The reaction tolerates various functional groups, and a variety of internal aryl alkynes were synthesized in 46-83% yields.
View MoreBeijing Mediking Biopharm Co., Ltd.
Contact:+86-10-89753524/81760121/81769521
Address:Hongxianghong Incubator, Beiqijia Town, Changping district, Beijing, China
website:http://www.antimex.com
Contact:0086-21-50563169
Address:Room1027,No.Jinyu Road,Pudong
Contact:86-532-68629711 13780605697
Address:NO 220 YANAN 3 ROAD,(POST ADMINISTRATION BUILDING),QINGDAO,CHINA
Synochem Ingredients Corp., Ltd.
Contact:+86-512-5636 2180
Address:Zhangjiagang Free Trade Zone
JIN TAN CHENG'EN CHEMICAL CO.,LTD.
Contact:86-519-82116250
Address:NO.102,village Dongfang,conomic development zone
Doi:10.1246/cl.1986.1809
(1986)Doi:10.1007/BF02494860
(1999)Doi:10.1021/ol8018743
(2008)Doi:10.1016/j.tetlet.2006.09.110
(2006)Doi:10.1021/acs.orglett.5b02835
(2015)Doi:10.1016/j.tetasy.2008.08.009
(2008)