Syntheses of 5,6,7- and 5,7,8-Trioxygenated 3',4'-Dihydroxyflavones Having Alkoxy Groups and Their Inhibitory Activities against Arachidonate 5-Lipoxygenase

DOI: 10.1021/jm00161a021

Source and publish data:

Journal of Medicinal Chemistry p. 2256 - 2262 (1986)

Update date:2022-08-04

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Authors:

Horie, Tokunaru

Tsukayama, Masao

Kourai, Hiroki

Yokoyama, Chieko

Furukawa, Masayuki

et al. et al.

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Article abstract of DOI:10.1021/jm00161a021

Arachidonate 5-lipoxygenase plays a pivotal role in the biosynthesis of leukotrienes.Cirsiliol (3',4',5-trihydroxy-6,7-dimethoxyflavone), a selective inhibitor of the enzyme, was derivatized by introducing alkyl groups of various chain lengths at position

Full text of DOI:10.1021/jm00161a021

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