10.1002/ejoc.201801721
European Journal of Organic Chemistry
COMMUNICATION
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Conclusions
In conclusion, we have developed a Ni(0)/PtBu3-catalyzed three-
component coupling reaction of TFE, aldehydes, and silanes that
affords fluorine-containing silyl ethers. Stoichiometric reactions
identified the oxidative cyclization of TFE and aldehydes with
Ni(0) as the key step in this catalytic reaction. The obtained
products can be deprotonated by a Lewis base and transformed
into 2,2,3-trifluoroallyl alcohols or organosilicon compounds,
which may be further used for the preparation of fluorine-
containing polymers and physiologically active compounds. The
present Ni-catalyzed system, which is based on the oxidative
cyclization between two different types of electron-deficient
substrates, may open new avenues for the preparation of a variety
of organofluorine compounds.
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This work was partially supported by Grants-in-Aid for Scientific
Research (A) (A16H02276) and (B) (16KT0057 and 17H03057)
from the Japan Society for the Promotion of Science (JSPS).
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Keywords: tetrafluoroethylene • nickel • three-component
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