Journal of Medicinal Chemistry p. 2268 - 2273 (1986)
Update date:2022-09-26
Topics:
Schoenenberger, Bernhard
Jacobson, Arthur E.
Brossi, Arnold
Streaty, Richard
Klee, Werner A.
et al.
The enantiomers of eseroline bind to opiate receptors of rat brain membranes with equal affinities and show opiate agonist properties as inhibitors of adenylate cyclase in vitro.However, only (-)-eseroline shows potent narcotic agonist activity in vivo, similar to that of morphine.Neither (-)-noreseroline, (+)-eseroline, nor the open dihydroseco analogue (-)-8 shows analgetic effects in vivo.The structure of rubreserine being a resonance hybrid of an o-quinone with its zwitterionic mesomer is confirmed by solid-state X-ray diffraction analysis.
View MoreLonghui qunfeng Chemical Co., Ltd
Contact:86-731-82173407
Address:South-east Industrial Park, Longhui County, Hunan Province, China
Contact:+86-574-89075960
Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
Reliable Pharma Technology (Shanghai) Co., Ltd.
Contact:0086-21-67676847-8008
Address:Lane 1500, No.68, Xinfei Road, Songjiang District, Shanghai, 201611, P.R.China.
JIAXING SUNS INTERNATIONAL TRADE CO LTD
Contact:18367306858
Address:No.123,Huixin Avenue,Huimin Dist
Contact:+852-8198 2399
Address:9E, Leapont Industrial Building, 18-28 Wo Liu Hang Road, Shatin, New Territories, Hong Kong
Doi:10.1016/j.bmcl.2016.01.014
(2016)Doi:10.1021/jo00369a049
(1986)Doi:10.1021/ja8007424
(2008)Doi:10.1016/j.tetasy.2008.05.020
(2008)Doi:10.1016/j.bmcl.2007.11.098
(2008)Doi:10.1016/j.tet.2008.05.011
(2008)
