Journal of Medicinal Chemistry p. 2268 - 2273 (1986)
Update date:2022-09-26
Topics:
Schoenenberger, Bernhard
Jacobson, Arthur E.
Brossi, Arnold
Streaty, Richard
Klee, Werner A.
et al.
The enantiomers of eseroline bind to opiate receptors of rat brain membranes with equal affinities and show opiate agonist properties as inhibitors of adenylate cyclase in vitro.However, only (-)-eseroline shows potent narcotic agonist activity in vivo, similar to that of morphine.Neither (-)-noreseroline, (+)-eseroline, nor the open dihydroseco analogue (-)-8 shows analgetic effects in vivo.The structure of rubreserine being a resonance hybrid of an o-quinone with its zwitterionic mesomer is confirmed by solid-state X-ray diffraction analysis.
View MoreXinjiang Zhongtai Chemical Co., Ltd.
Contact:+86-991-8788172
Address:NO.78 XISHAN RD.URUMQI，CHINA
HANGZHOU ZHONGCHANG SCIENTIFIC CO.,LTD
Contact:+86-571-88932183
Address:Hangzhou
lianyungang jinkang pharmaceutical technology co., ltd.
Contact:008651885445517
Address:Jinshan industrial park, Ganyu county, Lianyungang, Jiangsu Province, 222115, China
Contact:+44 7958 511245
Address:PO Box 469, Manchester, UK
website:https://www.sinoshiny.com/products
Contact:+86-20-62802632;62802633
Address:Room 330 GIGCAS Building,No.511 Kehua Street,Tianhe District
Doi:10.1016/j.bmcl.2016.01.014
(2016)Doi:10.1021/jo00369a049
(1986)Doi:10.1021/ja8007424
(2008)Doi:10.1016/j.tetasy.2008.05.020
(2008)Doi:10.1016/j.bmcl.2007.11.098
(2008)Doi:10.1016/j.tet.2008.05.011
(2008)
