Journal of Medicinal Chemistry p. 2268 - 2273 (1986)
Update date:2022-09-26
Topics:
Schoenenberger, Bernhard
Jacobson, Arthur E.
Brossi, Arnold
Streaty, Richard
Klee, Werner A.
et al.
The enantiomers of eseroline bind to opiate receptors of rat brain membranes with equal affinities and show opiate agonist properties as inhibitors of adenylate cyclase in vitro.However, only (-)-eseroline shows potent narcotic agonist activity in vivo, similar to that of morphine.Neither (-)-noreseroline, (+)-eseroline, nor the open dihydroseco analogue (-)-8 shows analgetic effects in vivo.The structure of rubreserine being a resonance hybrid of an o-quinone with its zwitterionic mesomer is confirmed by solid-state X-ray diffraction analysis.
View MoreContact:18710867521(wechat)
Address:Rm10516,Galaxy Tech Building #2,No.25 Tangyan Rd,Hi-Tech Zone,Xi'an, China
Shanghai Forever Biotech Co., Ltd.
Contact:+86-21-69734790
Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
Zhangjiagang Golden Reach Fine Chemical Co.,LTD.
Contact:+86-512-6585 6968
Address:Changfu Road， Dongsha Chemical Industry Park, Zhangjiagang City, Jiangsu Province, China
Nanjing Capatue Chemical Co., Ltd
Contact:+86-25-86371192 +86-025-85720158
Address:No.20 Jiangjun Avenue, Jiangning Economic & Technical Development Zone
Sichuan WeiKeqi Biological Technology Co., Ltd.
website:https://www.weikeqi-biotech.com/en
Contact:86-028-81700200
Address:sichuan Chengdu Qingjiang Zhonglu 63号
Doi:10.1016/j.bmcl.2016.01.014
(2016)Doi:10.1021/jo00369a049
(1986)Doi:10.1021/ja8007424
(2008)Doi:10.1016/j.tetasy.2008.05.020
(2008)Doi:10.1016/j.bmcl.2007.11.098
(2008)Doi:10.1016/j.tet.2008.05.011
(2008)
