Spiro Asymmetric Induction. Synthesis of Optically Pure α-Hydroxy Acid Derivatives by Alkylation of a Chiral Glycolate Enolate

Article abstract of DOI:10.1021/jo00369a049

The enolates of spiro-fused dioxolanones 4A and 4B serve as chiral glycolate enolate equivalents, providing either enantiomer of the α-substituted α-hydroxy esters 13 upon alkylation and hydrolysis