Journal of Medicinal Chemistry p. 2217 - 2225 (1986)
Update date:2022-08-03
Topics:
Oiry, J.
Pue, J. Y.
Imbach, J. L.
Fatome, M.
Sentenac-Roumanou, H.
Lion, C.
A variety of N-(aminoalkanoyl)-S-acylcysteamine and N,N'-bis(aminoalkanoyl)cystamine salt derivatives were synthesized. Toxicity and radioprotective activity (as the dose reduction factor DRF) were determined in vivo on mice and compared to WR 2721 and S-acetylcysteamine hydrochloride. One of the most interesting compounds of this series was N-glycyl-S-acetylcysteamine trifluoroacetate (16, I 102). Structure-activity relationships are discussed.
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