From phenothiazine to 3-phenyl-1,4-benzothiazine derivatives as inhibitors of the Staphylococcus aureus NorA multidrug efflux pump

DOI: 10.1021/jm701623q

Source and publish data:

Journal of Medicinal Chemistry p. 4321 - 4330 (2008)

Update date:2022-07-30

Topics:

Authors:

Sabatini, Stefano

Kaatz, Glenn W.

Rossolini, Gian Maria

Brandini, David

Fravolini, Arnaldo

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Article abstract of DOI:10.1021/jm701623q

Overexpression of efflux pumps is an important mechanism by which bacteria evade effects of substrate antimicrobial agents and inhibition of such pumps is a promising strategy to circumvent this resistance mechanism. NorA is a Staphylococcus aureus multid

Full text of DOI:10.1021/jm701623q

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