CHIRAL SYNTHESIS OF 3,4-DISUBSTITUTED 2-AZETIDINONES FROM (R,R)-(+)-TARTARIC ACID

DOI: 10.1016/S0040-4039(00)83934-9

Source and publish data:

Tetrahedron Letters p. 41 - 44 (1986)

Update date:2022-08-05

Topics:

Authors:

Gateau-Olesker, Alice

Cleophax, Jeannine

Gero, Stephan D.

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Article abstract of DOI:10.1016/S0040-4039(00)83934-9

A novel route is described for the enantioselective synthesis of 2-azetidinones 24 and 25 from (R,R)-(+)-tartaric acid.Monomethylation, monobenzylation of 2 and the use of site specific pig liver esterase (PLE) to produce 6 and 7 are the key steps in sequ

Full text of DOI:10.1016/S0040-4039(00)83934-9

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