HIGHLY STEREOSELECTIVE APPROACH TO CHIRAL BUILDING BLOCK POSSESSING THREE CONTIGUOUS ASYMMETRIC CENTERS. PREPARATION OF FOUR POSSIBLE DIASTEREOMERS OF β,β'-DIMETHYL-BIS-HOMOALLYLIC ALCOHOL DERIVATIVE

Article abstract of DOI:10.1016/S0040-4039(00)89229-1

All four diastereomers of chiral alcohol 2 with three contiguous chiral centers were stereoselectively prepared via diastereoselective addition of nucleophiles (crotyl metal or H(1-)) to α-methyl-β,γ-unsaturated carbonyl compounds 1.