Synthesis, Biological Activity, and Conformational Analysis of (2S,3R,4S)-MeBmt1-cyclosporin, a Novel 1-Position Epimer of Cyclosporin A

DOI: 10.1021/jm00128a048

Source and publish data:

Journal of Medicinal Chemistry p. 1982 - 1987 (1989)

Update date:2022-08-03

Topics:

Authors:

Rich, Daniel H.

Sun, Chong-Qing

Guillaume, Dominique

Dunlap, Brian

Evans, David A.

Weber, Ann E.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00128a048

Cyclosporin A (CsA, 1), an immunosuppressive cyclic undecapeptide, contains a unique amino acid, (4R)-4-<(E)-butenyl>-4,N-dimethyl-L-threonine (MeBmt), that appears to be critically involved in the biological activity of CsA.In order to further explore th

Full text of DOI:10.1021/jm00128a048

Products guided by the article

Product name:(4S)-3-((4'S,5'R)-5'-((1S,3E)-1-methyl-3-pentenyl)-2'-thioxo-4'-oxazolidinylcarbonyl)-4-(phenylmethyl)-2-oxazolidinone

Cas No:104418-82-8

R&D Labs maybe for 104418-82-8

Puyang Huicheng Electronic Material Co., Ltd

website:http://huichengchem.weba.testwebsite.cn/index_en.html

Contact:+86-393-8910800

Address:West Section Shengli Road, Puyang457000, China
Dalian Join King Biochemical Tech. Co., Ltd.

Contact:0411 39216206

Address:814 First State Blvd
Nanjing yieldpharma co.ltd

Contact:13813902930 025-52714267

Address:20 Fengji Road, Yuhua Economic Development Zone, Nanjing, Jiangsu, P. R. China
WEIFANG DERUN CHEMICAL CO.,LTD

Contact:86-536-8956886

Address:weifang
Heliosense Biotechnologies, Inc.

website:https://www.heliosense.com/

Contact:+86-592-5667290

Address:Xiamen Torch Hi-tech Zone Venture Weiye Building S506

Relevant to this article

Organic salts of pharmaceutical impurity p-aminophenol

Doi:10.3390/molecules25081910
(2020)
CAN-mediated highly regio- and stereoselective oxidation of vinylidenecyclopropanes: A novel method for the synthesis of unsymmetrical divinyl ketone and functional enone derivatives

Doi:10.1021/jo800829a
(2008)
Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity

Doi:10.1016/j.bmcl.2013.10.034
(2013)
Chain Transfer to Toluene in Styrene Coordination Polymerization

Doi:10.1002/anie.201914603
(2020)
Enantiomerization of chiral uranyl-salophen complexes via unprecedented ligand hemilability: Toward configurationally stable derivatives

Doi:10.1021/jo800610f
(2008)
N-<2-Hydroxy-5-<2-(methylamino)ethyl>phenyl>methanesulfonamide. A Potent Agonist Which Releases Intracellular Calcium by Activation of α₁-Adrenoceptors

Doi:10.1021/jm00380a017
(1985)

Article Doi