Synthesis, Biological Activity, and Conformational Analysis of (2S,3R,4S)-MeBmt1-cyclosporin, a Novel 1-Position Epimer of Cyclosporin A

DOI: 10.1021/jm00128a048

Source and publish data:

Journal of Medicinal Chemistry p. 1982 - 1987 (1989)

Update date:2022-08-03

Topics:

Authors:

Rich, Daniel H.

Sun, Chong-Qing

Guillaume, Dominique

Dunlap, Brian

Evans, David A.

Weber, Ann E.

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Article abstract of DOI:10.1021/jm00128a048

Cyclosporin A (CsA, 1), an immunosuppressive cyclic undecapeptide, contains a unique amino acid, (4R)-4-<(E)-butenyl>-4,N-dimethyl-L-threonine (MeBmt), that appears to be critically involved in the biological activity of CsA.In order to further explore th

Full text of DOI:10.1021/jm00128a048

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