First synthesis of 4,5-dihydro-3(2H)-pyridazinones via Zn-mediated hydrohydrazination

DOI: 10.1016/j.tetlet.2008.05.084

Source and publish data:

Tetrahedron Letters p. 4607 - 4609 (2008)

Update date:2022-09-26

Topics:

Authors:

Alex, Karolin

Tillack, Annegret

Schwarz, Nicolle

Beller, Matthias

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Article abstract of DOI:10.1016/j.tetlet.2008.05.084

The hydrohydrazination of 4-pentynoic acid with different arylhydrazines proceeds smoothly in the presence of zinc chloride. The domino amination-amidation sequence leads to aryl-substituted 4,5-dihydro-3(2H)-pyridazinones.

Full text of DOI:10.1016/j.tetlet.2008.05.084

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