Discovery of benzothiazole derivatives as efficacious and enterocyte-specific MTP inhibitors

Article abstract of DOI:10.1016/j.bmcl.2009.01.044

A series of triamide derivatives bearing a benzothiazole core is shown to be potent microsomal triglyceride transfer protein (MTP) inhibitors. In order to minimize liver toxicity, these compounds have been optimized to have activity only in the enterocyte