SONOCHEMICAL BARBIER REACTION WITH ISOCYANATES AND THE SYNTHETIC USE OF THE ORGANOMETALLIC INTERMEDIATE

Article abstract of DOI:10.1016/S0040-4039(00)85515-X

Sonication of aryl halides, t-butyl isocyanate and sodium in THF leads to an organosodium intermediate which is easily and regioselectively ortho-lithiated and reacted with electrophilic reagents.