SEARCH FOR METHODS OF SYNTHESIZING 1,9,10- TRIMETHOXY-2,3-METHYLENEDIOXYAPORPHINE.

Article abstract of DOI:10.1007/BF00576219

Several possible methods of obtaining 4-methoxy-2,3-methylenedioxybenzaldehyde have been considered.A method ensuring the synthesis of this aldehyde with a yield of 35-40percent has been developed which consists in the bromination of isovanillin followed by the replacement of the halogen by a hydroxy group and methylation.A number of substituted benzylidene- and benzyltetrahydroisoquinolines have been synthesized.It has been shown that the irradiation of these substances leads to N-dealkylation accompanied by oxidative processes.