(+/-)-(Z)-2-(aminomethyl)-1-phenylcyclopropanecarboxamide derivatives as a new prototype of NMDA receptor antagonists.

DOI: 10.1021/jm00015a019

Source and publish data:

Journal of medicinal chemistry p. 2964 - 2968 (1995)

Update date:2022-08-03

Topics:

Authors:

Shuto Shuto

Takada Takada

Mochizuki

Tsujita Tsujita

Hase Hase

Ono Ono

Shibuya Shibuya

Matsuda Matsuda

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Article abstract of DOI:10.1021/jm00015a019

(+/-)-(Z)-2-(Aminomethyl)-1-phenylcyclopropane-N,N-diethylcarbo xamide (milnacipran, 1), a clinically useful antidepressant, and its derivatives were prepared by an improved method and were evaluated as NMDA receptor antagonists. Of these, milnacipran (1)

Full text of DOI:10.1021/jm00015a019

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