Synthesis, Biological Evaluation, and Structure Analysis of a Series of New 1,5-Anhydrohexitol Nucleosides

DOI: 10.1021/jm00005a010

Source and publish data:

Journal of Medicinal Chemistry p. 826 - 835 (1995)

Update date:2022-07-29

Topics: Synthesis TLC Column chromatography Silica gel Dichloromethane Tetrahydrofuran Pyridine Dimethylformamide Refluxed Dioxane Lithium aluminium hydride Biological Evaluation Conclusion Structure Analysis Results and Discussion

Authors:

Verheggen, Ilse

Aerschot, Arthur Van

Meervelt, Luc Van

Rozenski, Jef

Wiebe, Leonard

et al. et al.

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Article abstract of DOI:10.1021/jm00005a010

In view of the selective anti-HSV activity of 1,5-anhydro-2,3-dideoxy-2-(5-iodouracil-1-yl)-D-arabino-hexitol, a series of novel 1,5-anhydrohexitol nucleosides were synthesized and evaluated for their inhibitory activity against several viruses.The 5-iodo

Full text of DOI:10.1021/jm00005a010

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